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Activated by the antibiotic rifampicin and numerous plant metabolites, which include hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-distinct. Activated by Normally occurring steroids, for example pregnenolone and progesterone. Binds to a reaction ingredient during the promoters on the CYP3A4 and ABCB1/M